Emmune Logo
Read The Science Behind Emmune.

AAV-Expressed eCD4-Ig Provides Durable Protection From Multiple SHIV Challenges

Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES Jr, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M Jr, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M.
Nature. 2015 Mar 5;519(7541):87-91.

By combining the parts of CD4 and CCR5 that are recognized by HIV onto a single synthetic antibody, eCD4-Ig disarms the features of HIV that allow it to resist antibodies that might otherwise interfere with receptor recognition and infection of susceptible T cells. Because eCD4-Ig is based on the receptor and co-receptor structures recognized by HIV, it recognizes all strains of HIV.

Cpf1 Proteins Excise CRISPR RNAs From mRNA Transcripts In Mammalian Cells

Zhong G, Wang H, Li Y, Tran MH, Farzan M.
Nat Chem Biol. 2017 Aug;13(8):839-841.

Cpf1 orthologs have RNase activities that can excise multiple CRISPR RNAs (crRNAs) from a single RNA polymerase II–driven RNA transcript expressed in mammalian cells. This property simplifies modification of multiple genomic targets and can be used to increase the efficiency of Cpf1-mediated editing.